Rabbit anti‑APP / Beta Amyloid Precursor IgG Polyclonal RW-C42820-0.1

Antibody: APP / Beta Amyloid Precursor Rabbit Polyclonal (C-Terminus) Antibody, Application: IHC-P, WB, Reactivity: Human, Mouse, Rat, Format: Unconjugated, Unmodified, Descriptio: Beta Amyloid Precursor antibody RW-C42820 is an unconjugated rabbit polyclonal antibody to Beta Amyloid Precursor (APP) (C-Terminus) from human, mouse and rat. Validated for IHC and WB., Targe: APP / Beta Amyloid Precursor, Synonym: APP | ABPP | A4 | ABETA | AD1 | Alzheimer disease | Amyloid beta | Beta-amyloid peptide | APPI | Beta amyloid | CVAP | AAA | PN2 | PreA4 | Amyloid beta A4 protein | Peptidase nexin-II | CTFgamma | PN-II | Protease nexin-II, Hos: Rabbit, Reactivit: Human, Mouse, Rat (tested or 100% immunogen sequence identity), Clonalit: IgG Polyclonal, Conjugation: Unconjugated, Purificatio: Purified, Modification: Unmodified, Immunoge: Synthetic peptide corresponding to amino acids 737-751 of human APP (C-TERMINAL)., Epitop: C-Terminus, Specificit: Recognizes both intact Amyloid Precursor Protein (APP), and also the C99 fragment generated by Beta-secretase. The sequence recognized by this corresponds to amino acids 85-99 of the C99 fragment. The C99 fragment itself is a substrate for gamma-secretase to generate the 4 kD beta amyloid peptide, found in the brains of Alzheimer's disease patients. APP also inhibits Notch signaling through it's interaction with NUMB. Has been used successfully for the detection of the ~14 kD beta C-terminal fragment of APP, produced as a result of cleavage by BACE1 using western blotting -in rat retinal lysates., Application: IHC - Paraffin
Western blot (1:500 - 1:1000), Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more: None, Usag: Immunohistology: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections., Presentatio: PBS, 0.02% Sodium Azide, Storag: Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate., Restriction: For research use only. Intended for use by laboratory professionals., Guarante: This antibody carries the RW 100% Guarantee., About APP / Beta Amyloid Precurso: Uniprot: P05067 NCBI: NM_000484 NP_000475.1